HHMI Faculty Research Award ( FRA ) Cover Sheet

نویسنده

  • Katharine Polasek
چکیده

keep the abstract under 1⁄2 of a page) Phantom limb pain adversely affects 64% of amputees and most treatment options are ineffective. The long term goal of my research is to develop a non-invasive, home-based therapy for treating phantom limb pain. This proposal focuses on the development of mathematical models for predicting effective electrode configurations and stimulation parameters in order to activate different portions of the nerve. Following this work, an algorithm will be developed to assign stimulation levels to each electrode and eliminate the need for perfect electrode placement. The first objective of this proposal is to determine which physiological and/or anatomical differences between motor and sensory axons explain the selective activation of sensation that has been found experimentally. These differences will be used in a mathematical model to predict axon firing and explain the different excitabilities. The second objective of this proposal is to determine an electrode configuration that predicts differential activation of the nerve. A previously-developed anatomical 3D model of the arm will be combined with the model from the first objective. This combination of models will be used to evaluate different electrode configurations. An effective electrode array will allow adjustment of the relative electrode activations to change which part of the nerve is active. This funding will provide significant summer research experience for at least two Hope students and further the field of biomedical engineering.

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تاریخ انتشار 2015